Grey's Anatomy (season 6)

Following the cliffhanger of season 5, Izzie is shown to have survived, but gets a bad wake up call: George's death. While the staff mourns the death of George, Meredith and the other residents are unsure how to continue with their lives as George's death poses a major impact to them all, leaving them each to deal with it in their own way.

Arizona stands by an enraged Callie when her father visits with a priest to attempt to convince her to renounce her homosexuality; and an accident derails a patient's upcoming kidney donation, with Dr. Bailey promising to set things right, segueing into a crossover with Private Practice. Following a kidney patient mishap, Izzie is fired from the hospital staff. After finding out it was because of the kidney patient, Izzie blames Alex, and leaves him a Dear John letter and evidently disappears.

Following the death of a patient, all the doctors concerned with the case are interviewed in a who-dunnit style. Owen, Cristina, Bailey, Alex, Callie, Lexie, Charles, Jackson and Reed all give their opinions and as the story unfolds we find out whose mistake was fatal.

Derek is asked by a hospital lab-tech, Isaac (Faran Tahir), to cure him when it turns out that he has an inoperable tumor surrounding his spine. Struggling with the impossible surgery, Derek attempts to do the impossible while he questions Richard's authority for attempting to deny him the operation.

Arizona is stunned when her longtime patient's parents offer the hospital a donation of twenty-five million dollars, but when her patient's condition worsens, all eyes are on her to save him. Cristina tests her relationship when she blatantly disregards Owen's orders and performs an unauthorised cardiac procedure, then later kisses Mercy Wester Jackson Avery at a surprise party for Arizona. Alex cares for a struggling newborn while Izzie remains missing. In the wake of great grief, Arizona and Callie take their relationship to the next level.

Izzie's back with an old teacher of hers that's ill. Derek operates on him. Alex confronts Izzie and she blames him for being fired. Richard Webber messed up on a surgery because he has too much on his mind so he plans on leaving surgery for a while, and you see a recap on how he starts drinking again.

The holidays aren't so merry for the doctors at Seattle Grace-Mercy West hospital when Cristina suspects that something is or has been going on between her boyfriend, Owen, and his old friend, Teddy. Bailey is stunned when her father makes rash judgements about her life and the choices she has made, finally culminating in a showdown at Meredith's Christmas dinner. Meanwhile, Alex is lonely since Izzie is still gone, while the Chief develops a steady addiction to alcohol.

Part 1 of a Grey's Anatomy/Private Practice crossover. The continued stay of Mark's daughter and his decision to adopt her baby when it is born rather than give it away creates tensions between him and Lexie. Meanwhile Addison Montgomery is called when a problem is discovered with Sloan's baby.

Izzie returns, after getting a message from Meredith suggesting Alex is moving on. She spends the day at the hospital attempting to win Alex back and looking for a job in the neighborhood. Torres gets the chicken pox and becomes incensed when Arizona locks her in isolation.

Meredith and Derek begin to discuss having a child, while Teddy and Mark have sex for the first time. Alex's brother comes to visit, which reveals many of Alex's secrets, much to the delight of Bailey and to the annoyance of Alex. Lexie begins to notice that April is developing a crush on Derek. Dr Webber, Lexie and Derek are faced with a patient that will come to change their lives forever.